The principles of radical surgery for cryptogenic gallbladder cancer: 1. If the postoperative pathological section reveals that the cancer only invades to the mucosal layer or muscle layer, complete cholecystectomy alone can achieve the purpose of radical treatment, so a second radical surgery is not necessary. The lymphatic metastasis of gallbladder cancer firstly involves the gallbladder triangle and the lymph nodes distributed along the common bile duct. 2.Cancer located in the gallbladder neck, especially in the gallbladder duct, occurs earlier due to its location near the gallbladder triangle. The postoperative recurrence rate of gallbladder neck cancer is also significantly higher than that of cancer at the base of the gallbladder body. Therefore, for occult gallbladder cancer located in the gallbladder neck and gallbladder duct, regardless of which layer of the gallbladder wall it invades, lymph node dissection around the hepatoduodenal ligament should be performed again. 3.For occult gallbladder cancer with infiltration depth exceeding the muscular layer, positive cut margin and positive gallbladder triangle lymph node biopsy, a second radical surgery should also be performed.