The gallbladder is a pear-shaped pouch structure located behind the liver under the right rib cage that concentrates and stores bile. The most common treatment for severe symptoms of cholecystitis, gallbladder stones and gallbladder polyps is cholecystectomy, including both laparoscopic and open cholecystectomy methods. “How can we digest food without gall bladder”, there are a lot of targeted solutions for patients faced by hepatobiliary surgeons in clinical practice. Is it true that people often say that they have no “guts”? The impact of a treatment on the body can be evaluated from two perspectives: immediate and long-term effects. In the case of laparoscopic cholecystectomy patients, front-line clinicians have a deeper understanding of this, because patients with post-operative discomfort will mostly go back to the surgeon for treatment, and according to our observation, about one-fourth of the general post-cholecystectomy patients have a slight feeling of distension after meals within two weeks, but these symptoms will gradually disappear in about a month. Of course, there are a few patients who report occasional pins and needles in the right upper abdomen even a few months after surgery. I think this may be related to the slight adhesion and pulling of the gallbladder bed and the abdominal wall or intestinal duct, which is harmless and does not require medication or injection. What is the role of the gallbladder? They think that the gallbladder has the function of digesting food and secreting bile, so naturally, without gallbladder, the digestive function is half as short as others. In fact, to use an analogy, the gallbladder is comparable to a small pond next to a reservoir, which can be filled with water to cushion the pressure of the reservoir’s capacity. Bile is secreted by the liver, the gallbladder only plays the role of temporary storage of bile, in turn, the gallbladder plays the role of regulating bile secretion, after the removal of the gallbladder, its role will be replaced by the common bile duct, there is no problem of loss of role. What are the long term effects of gallbladder removal on the body? In fact, there is no unanimous conclusion in the academic field because there is no rigorous statistical data to date to show the validity of this view, and I’m afraid that no one in the world has been able to investigate a large number of cases for decades, so naturally the reliability of this conclusion is questionable, isn’t it? Long-term follow-up of patients who underwent cholecystectomy for gallbladder disease showed a significant improvement in quality of life, with the benefits of resection far outweighing the benefits of non-resection in the long run. Excision for gallbladder stones eliminates the risk of gallbladder stones turning into bile duct stones, and removal of the gallbladder for multiple polyps or large polyps eliminates the risk of gallbladder cancer.