Hepatobiliary system stones are a collective term for intrahepatic bile duct stones, gallbladder stones, common hepatic duct and common bile duct stones, also known as cholelithiasis. It is a common and frequent clinical disease, and occupies the first place in the acute abdomen. Its etiology is complex, so far, although the painstaking efforts, but still not completely clear its direct cause. Roughly related to the following aspects. 1, gender (more women than men), age (25 – 50 years old), obesity, fertility, geography, dietary habits (two meals, like spicy wine and cheese, sweet and sweet, thick flavors), anxious and irritable, hereditary and some diseases. 2.Obstruction (stone embedded, parasites, etc., bile duct deformity, stenosis, scar). 3.Infection Hematogenous: sepsis, such as typhoid fever, paratyphoid fever, Escherichia coli, etc.; Hepatogenous: intestinal bacteria through the portal vein is not eliminated, intrahepatic bacteria, etc.. Ascaris lumbricoides carries bacteria: infection from intestinal tract upstream to biliary tract; other infections: such as burn, scalding, trauma, postoperative residual stone, etc. 4.Pancreatic fluid reflux Pancreatic digestive enzymes invade the biliary wall. 5.Abnormal lipid metabolism, bile acid, lecithin, cholesterol and other disproportionate. 6.Biliary stasis. It can be seen that in order to treat and prevent stones in the hepatobiliary system, it is necessary to target the cause and cut off the source. Play a role in preventing the recurrence of stones.