For the confirmation of the diagnosis of depression, there are four clinical aspects. The first aspect is history taking to understand the onset, development, and evolution of depression. Depression is clinically based on low mood, manifested as unhappy and sad; manifested as slow reaction of one’s brain, slow response, feeling like one’s brain is smeared with paste, unresponsive; no plan for the future; poor sleep quality, easy to wake up early; poor diet, eating without taste; low self-evaluation, feeling looked down upon; no interest, fun, things that used to be interesting The above symptoms occur most of the time every day. The above symptoms appear most of the time every day and affect work, study and life for more than two weeks, we highly suspect depression. The second aspect is psychiatric examination, which requires discussion with a psychiatrist to assess consciousness, sensation, perception, thinking, emotion, attention, willpower, memory, intelligence, and self-knowledge. The third is a scale test, which measures both self- and other-rated depression, and excludes related diagnostic tests, such as electrocardiogram and thyroid function. The final decision of depression is made by combining all the information. In terms of self-judgment, a more accurate diagnosis can be obtained through both symptoms and online self-assessment scales.