Sleep disorder is a common clinical condition, and benzodiazepines are often used to treat this condition. However, because of their addictive side effects and poor patient compliance, they often affect the therapeutic effect, and are a source of concern for physicians and patients. Chinese medicine is relatively safe and effective in treating insomnia, and its efficacy is long-lasting and consolidated, which is highly respected and recognized by doctors and patients. The author applied self-designed nourishing yin and restful sleep soup to treat 40 cases of insomnia with yin deficiency and fire evidence, and achieved more satisfactory results, which are reported below. 1. Diagnostic criteria All cases met the diagnostic criteria of insomnia of the Chinese Classification of Mental Disorders, 3rd edition (CCMD-3) [1]. Symptom criteria: (1) having insomnia as almost the only symptom, including difficulty falling asleep, poor sleep, excessive dreaming, early waking, or not easily re-sleeping after waking, discomfort after waking, fatigue, or daytime sleepiness, etc.; (2) having a dominant concept of insomnia and extreme concern for the outcome of insomnia. Severe criteria: dissatisfaction with the quantity and quality of sleep causes obvious distress after impaired social function. Disease duration criteria: occurring at least 3 times a week and for at least 1 month. Chinese medicine identification criteria: meet the criteria of the “Clinical Research Guidelines for New Chinese Medicines for Insomnia” Yin deficiency and fire evidence [2], symptoms: false irritability or dreamy and easy to wake up, dizziness and tinnitus, dry mouth and throat, irritable heat in the five hearts, palpitations and sweating, forgetfulness, or soreness and weakness of the waist and knees, seminal emission, irregular menstruation, red tongue and fine pulse. Inclusion criteria (1) Pittsburgh Sleep Quality Index (PSQI) scale score >7. (2) Stop taking other sedative-hypnotic Chinese and Western drugs during the treatment period. Exclusion criteria (1) With systemic diseases such as pain, fever, cough, surgery, etc., and those caused by external environmental factors interference. (2) Those who are under 18 years old or over 65 years old, pregnant or lactating women, or those who are allergic to this drug. (3) Combined with serious primary diseases such as cardiovascular, lung, liver, kidney and hematopoietic system, psychiatric patients. (4) Those who do not use the drug as prescribed, cannot judge the efficacy or have incomplete information that affects the judgment of efficacy and safety. (5) Those who are allergic to the drugs in Nourishing Yin and Sleeping Soup. 2. Criteria for determining the efficacy (1) The efficacy criteria were formulated according to the Clinical Research Guidelines for the Treatment of Insomnia with New Chinese Medicines [2]. Clinically cured: sleep time returns to normal or sleep for more than 6 hours at night, deep sleep, and full of energy after waking up. Significantly effective: significant improvement in sleep, sleep time increased by more than 3 hours and sleep depth increased. Effective: The symptoms are reduced and the sleep time is increased by less than 3 hours compared with before. (2) The clinical efficacy was assessed by the Pittsburgh Sleep Quality Index (PSQI) scale, which indicates poor sleep quality if PSQI>7 and good sleep quality if PSQI≤7. The basic formula is: 30g of lily, 15-30g of raw earth, 10g of Zhi Mu, 6g of lotus seeds, 15-20g of fried jujube, 15-30g of Shou Wu Tang, 15g of Fu Shen, 15-20g of Cyperus rotundus, 10-15g of Shu Di, 10g of Cornus officinalis, 3-6g of roasted glycyrrhiza, 3-6g of sandalwood. Add and subtract: if accompanied by lumbar and knee weakness, add 20~30g of Radix Rehmanniae and 15g of Cornu Cervi Pantotrichum; if seminal emission is seen, add 10g of Cyperus rotundus, if menstruation is preceded or low, add 10g of Colla Corii Asini. 1 dose daily with water decoction, taken between 11:00 and 13:00 noon and 2 hours before bedtime, respectively. In the control group, eszopiclone tablets (produced by Beijing Yimin Pharmaceutical Co., Ltd., State Drug Administration No. H11020891) were taken orally 1~2mg once daily before bedtime. The duration of treatment was 4 weeks in both groups, and then the efficacy was judged. 3. Discussion Insomnia is called “sleeplessness” in Chinese medicine. It manifests as difficulty in falling asleep, waking up from time to time, unstable sleep or inability to fall asleep again after waking up. According to TCM, imbalance of yin and yang is the key to this disease. The heart is fire, which is the master of the mind, and the kidney is water, which is the internal source of yin and yang. Physiologically, if the heart and kidneys meet, water and fire will be in harmony with the yin and yang in the body, the yin will be calm and the yang will be secret, and the spirit of the internal code of sleep will be normal. If the heart and kidneys do not intersect with water and fire, the heart and fire will be inflamed and the yin and blood will be depleted, resulting in insomnia. Clinically, insomnia caused by Yin deficiency and fire is the most common. Chinese medicine must seek to treat the root of the disease. Insomnia is an external manifestation, which is the standard; physical bias is the internal foundation, which is the root. According to Chinese medicine physical science, insomnia is also one of the diseases that Yin deficiency quality is prone to, and Yin deficiency quality is one of the important physical factors for its development. In particular, “Shao-Yin Yin deficiency people are weak, fear heat, like to think, have a tendency to insomnia, sexual function deficiency hyperactivity, the onset of fever, heart trouble, insomnia, five heart trouble, spermatorrhea and other evidence (Shao-Yin heat transformation evidence). Among the 172 cases of insomnia collected by Sun Guangren et al. in their clinic, Yin deficiency was found to be in the first place, which is consistent with the clinical observations of the author. In order to improve the efficacy, compliance and quality of life of patients, and to comprehensively improve the yin-deficiency quality of insomnia, the author has sought to treat the body, disease and evidence together. Therefore, I use Baihe Dihuang Tang and Baihe Zhimu Tang from “The Essentials of the Golden Horoscope”. After clinical verification by many physicians, both formulas have good effect of nourishing yin and clearing heat and tranquilizing the mind, so on this basis, we added flavor to form our own “Nourishing Yin and Tranquilizing Sleep Soup”. This formula takes lily as the monarch to nourish yin and clear the heart and tranquilize the mind; the subject medicine, raw earth and Zhi Mu, nourish yin and clear heat and clear heat; lotus seeds clear the heart and lower the fire, dipping the south to supplement the north, so that water and fire can both help and the mind can be tranquilized; adjuvant shouwu vine, cypress seeds, fried jujube seeds and porcupine, to strengthen yin and nourish blood to tranquilize the mind; adjuvant rehmannia and dogwood, to nourish kidney yin and nourish yuan yin to benefit the root, which is also the root and key to improving yin deficiency; roasted licorice as the herb, to harmonize all the medicines, and It can nourish the heart by tonifying the deficiency and the middle, and the pungent taste and warmth of sandy nuts can move stagnation and awaken the spleen, avoiding this formula from nourishing the diaphragm and damaging the spleen and stomach; it is also good at entering the kidneys, passing through the three jiao, reaching the fluids, and collecting the essence of the five viscera and six internal organs and returning it to the kidneys. The whole formula works together to nourish yin, clear heat and calm the mind for restful sleep. The results of clinical efficacy observation in this paper showed that the total effective rate of insomnia patients in both groups after treatment was 95% in the treatment group and 80% in the control group; the results of PSQI score after treatment were (6.55±1.867) in the treatment group and (7.73±2.708) in the control group, and the total effective rate and total PSQI score in the treatment group had a significant decrease compared with the control group (P＜0.05). In the control group, 14 patients showed dry mouth and constipation, 11 patients showed headache, dizziness and weakness, and drowsiness, while no adverse effects were found in the treatment group. The efficacy of Zhiyin Ansiang Tang in treating Yin deficiency and fire type insomnia is more satisfactory, with higher safety, better compliance and no adverse reactions, which needs further clinical improvement and research.