Many people with depression and their families believe that depression is a mental illness and therefore “the heart needs medicine”. They believe that depression can be treated with psychotherapy alone and that medication is not needed and should not be used to treat depression. In fact, this view is one-sided or incorrect. Modern medical research has found that there are many biological factors in the pathogenesis of depression, especially in patients with moderate or severe depression. In this respect, medication plays a very important role in the treatment of depression, especially in moderate and severe depression. It is important to note that depression must be treated systematically and standardized from the beginning, and patients must have the correct awareness of medication, adhere to the full amount and duration of treatment, and regularly follow up at the hospital. It should be noted that the effect of depression medication is slow, and most of the patients need 2~3 weeks to see the effect after taking the medication. In clinical practice, we often find that some patients stop taking medication or switch to other medication after a few days of feeling the effect is not obvious, which makes the condition more complicated and difficult to treat. Generally, the depressive symptoms will be relieved or disappear after 3~4 months of effective medication, and the patient’s social function will be gradually restored, which is what doctors consider as clinical cure. But clinical cure is not the same as complete cure, if patients stop taking medication at this time, many symptoms may recur. Because depression is not an acute disease, but a chronic, recurrent disease, patients who have had one episode of depressive disorder have a relapse rate of at least 50%, and patients who have had two episodes have a relapse rate of 80% to 90%. For patients with depressive disorders, adequate medication and long-term medication maintenance are essential, so patients with depression who have a first episode and achieve clinical recovery should continue medication treatment for 4-9 months during the consolidation period, and patients with first-episode depression generally need 9-12 months of total medication duration. The first treatment of depression is particularly critical, and if the first treatment is adequate, it can greatly reduce the rate of subsequent relapses. If a second episode occurs, the patient should maintain treatment for more than 2 years. Those with multiple relapses should be treated with long-term medication maintenance. Psychotherapy also plays a very important role in the treatment of depression. Depression medication is more effective when combined with psychotherapy. Psychotherapy can somehow change patients’ bad way of thinking, help them analyze and explore themselves, solve psychological conflicts, release and detoxify repressed emotions, and reduce patients’ inner pressure and burden. A lot of medical research proves that if the family and friends of depressed patients can really understand and care about them, the medication will be effective. If the patient is not understood and friends and relatives around give some bad stimulation intentionally or unintentionally, the medication is not effective and the treatment lasts longer. Commonly used psychotherapy methods include cognitive behavioral therapy, supportive psychotherapy, behavioral therapy, Morita therapy, etc. Clinicians will choose the appropriate psychotherapy method to treat patients according to their actual situation.