1.Loss of interest, no sense of pleasure. 2.Loss of energy or fatigue. 3.Psychomotor retardation or agitation. 4. Low self-esteem, self-blame, or feelings of guilt. 5.Difficulty in association or reduced ability to think intuitively. 6.Recurrent thoughts of death or suicidal or self-injurious behavior. 7.Sleep disorders, such as insomnia, early awakening, or excessive sleep. 8.Decreased appetite or significant weight loss. 9.Decreased sexual desire.