The treatment of malignant pleural effusion caused by lung cancer is complicated and controversial. Its treatment methods mainly include local intrathoracic chemotherapy, immunotherapy, biological therapy and Chinese medicine treatment. It has been reported that the efficacy of thoracoscopic talc pleural fixation for malignant pleural effusion is reliable, but the incidence of postoperative complications such as fever, severe chest pain and respiratory failure is high, which is not easily accepted by patients. Intrathoracic thermal perfusion therapy and combined intrathoracic thermal perfusion chemotherapy for malignant pleural efficacy of lung cancer have been confirmed by many domestic and foreign research institutes, especially for those old and frail patients with poor cardiopulmonary function and malnutrition, we performed thoracic high-temperature perfusion chemotherapy under thoracoscopy, which has the advantages of less trauma, faster recovery, less complications and exact efficacy, and achieved better results. After treatment, all patients’ preoperative symptoms such as chest tightness, dyspnea and palpitation were significantly relieved or disappeared, pleural fluid was controlled, quality of life was improved, and survival time was prolonged.