Patient: Hello! My colposcopy report is: CIN3 with involvement of glands. The pathology after LEEP is: chronic inflammation with focal CIN1 and no abnormal hyperplasia at the margin. I don’t know why a CIN lesion would occur despite being negative for HPV. I asked my primary care physician, but he did not have a clear explanation, so I am asking for your advice and hope to get your reply. In addition, in my case, apart from paying attention to hygiene, what else should I pay special attention to, and can I take some health supplements to improve my immunity? The actual fact is that you can find a lot of people who have been in the business for a long time, and they’ve been in the business for a long time. However, although the LEEP is CIN1 (low grade lesion), we still take the highest grade lesion as your final clinical diagnosis, so you are still a “histologically confirmed CIN3 patient”. It is important to note: 1. Follow-up: CIN3, even if the LEEP margins are clean, still requires standardized follow-up in the future: every 6 months after surgery, by TCT, or TCT + colposcopy. After 3 consecutive follow-ups (i.e., after 1.5 years), the follow-up can be changed to annual follow-ups. 2. Use condoms for sex (i.e. barrier method): condoms can reduce the occurrence of reproductive tract infections while providing effective contraception. 3, maintaining a healthy mind, balanced diet, and proper fitness is fundamental to improving immunity. Health care drugs are only the icing on the cake. About HPV: There are many methods to detect HPV, I don’t know which one you are using. Most clinical applications are for the FDA-approved HC-2 method, which is designed to detect the 13 most common high-risk HPV types, and persistent high-risk HPV infection is a major cause of high cervical lesions and cervical cancer. However, not all high cervical lesions and cervical cancer are due to HPV; another possibility: if your CIN3 is infected with HPV of subtypes other than those 13, HC-2 will not detect it. Therefore it is understandable that you are HPV negative. The current treatment principle for cervical lesions is “treating the disease but not the virus”, i.e. treating the lesions caused by the virus but not the virus itself. HPV negative or positive only reflects the status of the virus infection and is only used as a reference condition for doctors to judge the condition. I hope my answer can help you, wishing you a speedy recovery.