Glutamyl transpeptidase is an enzyme that catalyzes the γ-glutamyl group transfer reaction and is widely found in various tissues such as liver, bile, pancreas, heart, kidney and prostate, etc. It is especially abundant in liver, kidney and pancreas, but glutamyl transpeptidase in serum mainly comes from the hepatobiliary system. The normal reference value of glutamyl transpeptidase is 3-50U/L. Elevated glutamyl transpeptidase can be seen in frequent alcohol consumption, biliary tract disorders or malignant tumors, medication, as well as coronary heart disease, metabolic syndrome and insulin resistance. And high glutamyl transpeptidase in newborn is mainly seen in hepatobiliary disease, specific reasons are as follows: 1, newborn accidentally sucked a small amount of amniotic fluid at birth or due to other infectious reasons, resulting in newborn suffering from pneumonia, which can cause elevated glutamyl transpeptidase; 2, if the newborn has biliary obstruction, due to congenital biliary atresia, causing human bile can not be excreted, resulting in neonatal jaundice, check the liver function related indicators may Glutamyl transpeptidase will be high. In conclusion, when a newborn develops jaundice or related symptoms, such as yellowish skin and sclera, poor response, coma, and respiratory distress, he/she should immediately seek medical attention to find the cause and treat the cause, so that the glutamyl transpeptidase can return to normal.