Indirect bilirubin is also known as unconjugated bilirubin, i.e. bilirubin that is not bound to glucuronic acid. Total bilirubin is composed of indirect bilirubin and direct bilirubin. The causes of increased indirect bilirubin in newborns are: 1. Excessive bilirubin production: common in erythrocytosis, cranial hematoma, intracranial hemorrhage, subcutaneous hematoma, hemolysis in mother-child blood type incompatibility (ABO or Rh blood type incompatibility is common), infection, breastfeeding-related jaundice, breast milk jaundice, G-6-PD deficiency, thalassemia, etc.; 2. Impaired bilirubin metabolism: hypoxia, congenital UDPGT deficiency, congenital hypothyroidism, trisomy 21, GibertZ syndrome, familial transient neonatal jaundice, etc. Newborns presenting with high indirect bilirubin should seek prompt medical attention. If the jaundice manifests as hemolytic, it usually worsens gradually within 24 hours of birth. Color changes after birth, which can manifest as yellowing of the eyes and other conditions, require early examination at the hospital. Mild cases can be treated with blue light irradiation, while severe cases require blood exchange therapy. With timely treatment, jaundice symptoms will subside on their own, leaving no sequelae and not affecting the baby’s growth and development or other functions, and should be detected and treated as early as possible.