Many people have questions about whether gallbladder stones require surgery, when to operate, and what is the better procedure. In principle, if the diagnosis of gallbladder stones is clear, surgery should be performed to remove the gallbladder to prevent acute cholecystitis or other serious complications caused by gallbladder stones, such as common bile duct stones, acute cholangitis and acute pancreatitis. In general, asymptomatic gallbladder stones can be removed without immediate cholecystectomy, but the surgery should be elective. However, if there is one of the following conditions, cholecystectomy needs to be done as soon as possible (1) recurrent symptoms or acute cholecystitis; (2) large stones (2-3 cm) and large number of stones, especially those with a long history (more than 10 years), which have the risk of gallbladder cancer; (3) older age (>60 years), with hypertension, cardiac insufficiency, diabetes mellitus, etc. —– because once the complication of gallbladder stones occurs, the morbidity and mortality rate is extremely high; (4) The gallbladder is full of stones or porcelain gallbladder, the gallbladder is already non-functional, and it is easy to complicate gallbladder cancer, so early removal is appropriate; (5) in remote mountainous areas and poor medical conditions, early preventive removal should be done. —— Once serious complications such as acute cholecystitis or acute pancreatitis occur, they are often incurred due to untimely treatment. Laparoscopic cholecystectomy (commonly known as “eyelet”) is currently the classic procedure for the treatment of gallbladder disease and is preferred. However, there are some patients who are not suitable for “eye surgery” and need open cholecystectomy, mainly in the following two cases: (1) suspected or confirmed malignant gallbladder lesions; (2) history of complex surgery in the upper abdomen and serious intra-abdominal adhesions.