Patients with more than 4 somatic complaints but no clear diagnosis should be screened for depression and anxiety. 4 questions to screen for depression 1. Do you feel depressed, pessimistic and disappointed about life? 2. Are you not interested in things you usually like? 3, do you feel easily tired, lack of energy? 4.Do you sleep differently than usual? If you answer “yes” to more than 2 questions, you should pay attention to the possibility of depression and anxiety.