Lung metastasis is more common among other organ metastases in primary hepatocellular carcinoma. According to the past treatment experience, some doctors advised patients and family members not to take active and aggressive treatment anymore, which is very cruel and unacceptable to patients and family members. The use of targeted therapeutic drug sorafenib has brought light to the treatment of patients. The clinical use of minimally invasive treatment such as argon helium knife cryoablation therapy combined with sorafenib, but also the choice of TACE (hepatic artery chemoembolization) combined with sorafenib treatment, through the experimental observation of some patients appear to lung metastases shrink or disappear, the primary foci stable, can effectively control the disease progress. Of course, we should also pay attention to the adverse effects of taking sorafenib such as: skin damage on hands and feet, hair loss, hypertension, diarrhea, etc.