Hepatitis B patients with chronic hepatitis B have continuous replication of the hepatitis virus in their bodies, thus causing continuous inflammatory activity in the liver and worsening of hepatic fibrosis, leading to cirrhosis in the worst case scenario. Therefore, for cirrhotic patients with viral replication, in addition to the need to interrupt the development of liver fibrosis, it is also necessary to do the fundamental treatment – antiviral therapy, only in this way can we eliminate or reduce the immune response from the root, thus playing the role of the bottom of the barrel. Early antiviral treatment of cirrhosis is very important, the correct use of antiviral therapy drugs can not only improve liver function and clinical symptoms, but also is expected to prolong the patient’s survival period and improve the quality of life of patients. How to choose antiviral drugs for hepatitis B cirrhosis? Antiviral therapy for early and middle stage cirrhosis Interferon has antiviral, antifibrotic and immunomodulatory effects, and can be used in the treatment of early and middle stage cirrhosis. Some studies show that long-term treatment with interferon for patients with liver fibrosis and early cirrhosis can stabilize the condition. Another study reported that some of the 490 patients with chronic hepatitis or post hepatitis cirrhosis were treated with interferon, confirming that interferon can effectively reduce the risk of hepatocellular carcinoma and that none of the patients progressed to decompensated cirrhosis after interferon treatment. Treatment of cirrhosis with interferon is generally recommended to be safer in small doses. In a study of long-term treatment of cirrhotic patients with hepatitis B with low-dose interferon, after 1.5 to 7 years of follow-up, ALT decreased to normal level in 66% of cases, with HBV DNA and HBeAg turning negative, and no serious complications occurred during interferon treatment. It should be noted that the efficacy of interferon is positively correlated with the dose (the efficacy increases with the increase of the dose), so the treatment of cirrhosis with interferon must be tolerated by the patient under the premise of interferon, as much as possible, increase the dose of interferon in order to obtain the best therapeutic effect, and at the same time, we need to be vigilant against the occurrence of side effects of interferon. Antiviral treatment for advanced cirrhosis Patients with advanced cirrhosis of chronic hepatitis B have clinical manifestations of liver failure and complications related to portal hypertension. The goal of treatment at this point is to improve liver function and delay or reduce the need for liver transplantation. Considering the possible side effects of interferon, it is recommended to use nucleoside (acid) drugs with a lower incidence of drug resistance for these patients, and closely monitor drug resistance during the course of treatment, and give rescue therapy as soon as drug resistance is detected.