Psychotherapy is only applicable to patients with mild depression, depression in remission and chronic depression. Common clinical psychological treatments for depression include cognitive behavioral therapy, supportive psychotherapy, and family therapy. The psychiatrist will develop a treatment plan according to your specific situation. For patients with major depression, psychotherapy is often extremely dangerous. There have been many cases in China about counselors not recognizing depression and advising patients not to take medication eventually leading to suicide. Treatment of depression should take into account the severity of the patient’s depression and the importance of individual differences. The pathogenesis of depression is due to low levels of neurotransmitters such as pentraxin in the brain. Psychotherapy has little effect on raising the level of central neurotransmitters, and medication must be used to raise the level of central pentraxin and other neurotransmitters, so medication is the basis of treating depression. Antidepressants generally take effect in 2 to 4 weeks, must be patient and continue to take the drug, observe six weeks invalid, and then consider changing the drug, take the drug on time and in accordance with the dosage, do not pay too much attention to the drug instructions in a wide range of side effects. When the medication takes effect depression symptoms gradually alleviated and then combined with psychotherapy. The emphasis on psychotherapy may delay the disease and miss the best time for treatment. At present, the clinical treatment of depression tends to be more and more integrated application of drugs and psychotherapy, which can not only reduce or alleviate the patient’s symptoms, but also improve the patient’s psychosocial adaptation level, enhance the patient’s treatment compliance and improve their quality of life, which is the most effective treatment method.