The main symptoms are anal itching, ulcers or pain, hard chancre and flat warts. 1. Anal itching: This is a possible symptom of the perianal area during syphilis. It is a good idea to take a look at the website to see if you can find the best way to get the most out of your website. If you scratch the itchy area, it will not only aggravate the itching, but also produce serious skin breakdown. 2. Anal ulcers or pain: This can be caused by skin breakdown, cracking or co-infection, resulting in pain when touching the anal area or pain when defecating. 3. Hard chancre: A hard chancre may appear in the perianal area of patients with stage I syphilis, which is a transient, painless ulcer that will heal on its own after about a month. 4. Flat warts: These appear as In addition to these symptoms, syphilis can also involve other systems in severe cases and may cause nausea, bloating, constipation, diarrhea, dizziness, insomnia, and irritability.