Patient Female, 73 years old. She was admitted to the hospital 2 months after interventional chemotherapy for right liver tumor, with abdominal distension and pain with fever for 10 d. Two months ago, she discovered a large mass in the right upper abdomen on her own, and CT examination suggested a large occupancy of 16 cm × 13 cm × 10 cm in the right lobe of the liver, which was considered to be a hepatic malignant tumor after enhancement. Pathological diagnosis: hypofractionated cell carcinoma, treated with transhepatic artery embolization chemotherapy for 2 times. 10d ago, sudden abdominal pain with fever. Physical examination: anemic appearance, no yellow stain on skin and sclera. A huge mass in the right upper abdomen, reaching down above the anterior superior iliac spine, was tough, cystic, slightly mobile, and without pressure pain. Tumor markers: CEA, CA199 and AFP were all within normal range. Hepatitis B serum test was positive. The CT examination showed that the right posterior lobe of the liver had an exophytic giant mass, about 25 cm × 20 cm × 15 cm in size, irregularly lobulated and cystic, with uneven density, scattered iodine oil deposition high-density shadow, and a lamellar hypodense area in the center, and the parenchymal part of the arterial Zhang Jianping of Jinan Military Hospital Hepatobiliary Surgery Department was unevenly enhanced after enhancement, and the adjacent colon and duodenum were compressed and displaced with unclear boundaries. Diagnosis: primary hepatocellular carcinoma. Intraoperatively, it was confirmed that the tumor originated from the lower edge of the right posterior lobe and showed exophytic growth. Postoperative pathology: sarcomatoid hepatocellular carcinoma with cystic changes and hemorrhage. Immunohistochemistry: CK19 (-), AFP (-), hepatocyte?1 (-). He was discharged from the hospital 12d postoperatively cured. Follow-up for 5 months was good.