1, acute cholecystitis attack: gallstones can cause biliary colic, epigastric vague pain and abdominal distension, indigestion outside; 2, liver infection, liver abscess: the spread of cholecystitis, resulting in the spread of inflammation to the surrounding area, causing liver function damage, causing jaundice, and even liver abscess. 3, pancreatitis: inflammation of the biliary tract can often cause biliary pancreatitis. It makes the disease more complicated and serious, and even life-threatening, leading to death. 4, bile duct stones: small gallbladder stones sometimes drain into the bile duct causing secondary bile duct stones, which can cause cholangitis and also complicate the disease. 5.Gallbladder cancer: Gallbladder stones can also cause cancer if they stimulate the gallbladder wall for a long time.