The incubation period of syphilis varies from person to person, generally ranging from 9-90 days, depending on the patient’s individual constitution and the number of syphilis spirochetes entering the body, with the onset of symptoms starting in 2-4 weeks in most cases. Syphilis is a sexually transmitted disease caused by infection with syphilis spirochetes, and symptoms usually appear after 2-4 weeks of high-risk sex. The incubation period is the period from exposure to the pathogen to the onset of the disease. The incubation period for syphilis can be as short as 9 days or as long as 90 days, with an average of several weeks, due to factors such as the individual’s physical condition, the number of syphilis spirochetes entering the body, the prognosis for treatment, and the patient’s degree of cooperation. It is recommended that people suspected of syphilis infection should be examined several times, even if a test is negative, it cannot be ruled out immediately, but should be examined again after a month, which is conducive to accurate diagnosis and treatment. In addition, it is important to keep regular work and rest, be clean, pay attention to personal hygiene and eliminate high-risk sexual behavior.