Liver fibrosis is a necessary stage in the progression of chronic hepatitis to cirrhosis. At this stage, the most important pathological change in the liver is the formation and deposition of extracellular matrix (collagen, non-collagenous glycoproteins, proteoglycans) in large amounts in the liver. In the early stage, the deposition only occurs in the interstitial space of hepatocytes, but in the later stage, the fibrous proliferation extends to the interstitial space of liver parenchyma cells and gradually forms fibrous cords and fibrous intervals, and in the final stage, the fibrous intervals join to form fibrous wraps, leading to the appearance of the typical pathological features of cirrhosis – pseudobullet generation, which is the cirrhotic stage. Some patients with chronic hepatitis are interested in knowing the formation of fibrosis in their liver and the degree of fibrosis, so the clinician gives them a serum fibrosis quadruple test for determination. These four indicators include serum collagen type III (PC III), serum collagen type IV (V VI), laminin (LN), and hyaluronic acid (HA). It has been clinically verified for many years that these four serological indicators can basically reflect the situation of liver fibrosis. If only one of the four indicators is elevated, the liver may have started to develop fibroplasia; if two or three indicators are elevated, there is significant fibroplasia. Of course it is still difficult to determine the degree of fibroplasia in the liver (i.e., the aforementioned liver fibrosis staging) based on the results of serological fibrosis index testing alone. When all fibrosis indicators are elevated to varying degrees, especially when hyaluronic acid (HA) is elevated several-fold or more, a high degree of fibrosis or even early cirrhosis should be considered, although doctors sometimes have to combine other data to make a comprehensive analysis.