Depression is a manifestation of increased negative emotions. Patients are depressed, sad, depressed, pessimistic and despairing, feeling useless, uninteresting, self-condemnation, even suicidal ideas and behaviors, “life is like a year”, “life is worse than death”, often accompanied by slow thinking and The feeling of “life is better than death” is often accompanied by slowed thinking and reduced speech and movement. However, the whole mental activity is still closely related to the surrounding environment. Patients often describe their mood as bad, depressed, unhappy, desperate, frustrated, empty, very sad, very helpless, and uninterested in anything, and the observation of others can be described by no smile, few words, negativity, sad face, very dull, weepy, sentimental, decreased efficiency, cynicism, and laziness. Core symptoms: low mood (despair, helplessness, sense of uselessness) independent of the external environment, almost every day for at least 2 weeks (76%); lack of interest (loss of cheerfulness) (86%); low energy (fatigue) (73%). Psychological symptoms: anxiety (may be accompanied by somatic symptoms) (57%), self-blame, psychotic symptoms (hallucinations, delusions, etc.), cognitive symptoms (decreased attention, memory, pessimism), suicidal ideation and behavior, incomplete self-awareness, psychomotor retardation (82.2%) (slowed thinking, decreased work efficiency, severe wood stiffness) or agitation. Somatic symptom group: sleep disorders (waking up more than 2 hours early, sleepiness) (63-72.5%), appetite disorders, weight loss (more than 5% from the previous month), sexual dysfunction (46%), loss of energy (fatigue, inability to regain strength even after rest, lack of energy), heavy daytime and light nighttime (endogenous), non-specific somatic symptoms (pain, peripheral discomfort, panic, shortness of breath, urinary frequency, urinary urgency, etc.).