Stage II syphilis usually appears 7-10 weeks after infection with the syphilis spirochete. The clinical manifestations vary, most patients have low fever, headache, muscle and joint pain, etc. Some patients have enlarged liver and spleen and enlarged lymph nodes; some patients have syphilis rash, which is non-specific, usually red papules, macules, etc., with skin and mucous membrane damage; some patients have no joint damage; some patients have neurosyphilis, which usually has There are also some patients with neurosyphilis, usually with abnormal cerebrospinal fluid and signs of meningeal irritation. Patients with second-stage syphilis need timely anthelmintic treatment, and the drug of choice is usually penicillin for about 2-3 weeks. For patients with penicillin allergy, tetracycline and macrolide drugs can be chosen.