Patient: At the beginning of the year, high platelet count was found to be over 700, and the jak2 test result was positive. In early April, I started to inject 300 units of ganercept 3 times a week, and my platelet count has dropped to over 410. I heard that there is an imported drug called Anagrelide to treat this disease, how safe and effective is this drug? (I am 68 years old) Fan Lei, Department of Hematology, Jiangsu Provincial People’s Hospital: If the economy permits, long-term maintenance with interferon is possible. The drug Anagrelide has not been officially introduced into China yet. Patient: Director Fan s thank you for answering my inquiry yesterday. I would like to continue to consult you. I have had 19 injections of interferon so far, and I had a large reaction to the first injection, with a fever of 39 degrees (with antipyretic medication) r After that (including today) there were several low fevers of 37.3-38 degrees, with mild chills, which returned to normal after a few hours without antipyretic medication. Will the fever become normal on the day after the injection? Will the body slowly adapt and not have fever? Fan Lei, Department of Hematology, Jiangsu Provincial People’s Hospital: You can take an aspirin or similar drug before the injection to reduce the side effects of the drug. Patient: Hello, Director Fan s! If I take antipyretic medicine in advance every time, I am worried about hurting my stomach, I suffer from gastroesophageal reflux and chronic gastritis, will I lose sight of this? I would like to know if there is a long-term fever reaction to interferon? Is there an adaptation process? The majority of patients have uncomfortable reactions in the early stages of interferon treatment, which will gradually improve. If you can’t tolerate it, you can switch to hydroxyurea. Patient: Director Fan’s reply is very timely, thank you! Patient: Question: [IG] juvenile granulocytes 0.7 is a big problem Disease: primary thrombocytosis, diabetes, hypertension Description (onset time, main symptoms, hospital visited, etc.): Director Fan s recently did routine blood tests ¸ results showed s [IG] juvenile granulocytes 0.7, [IG|] juvenile granulocytes 0.06, [HCT] erythrocyte ratio 38.1, platelets 357, platelet ratio 0.34, white blood cells 8.42, red blood cells 4.22, hemoglobin 123, average red blood cell volume 90.3, average hemoglobin volume 29.1, average hemoglobin concentration 323, the rest of the routine blood test results are within the normal reference range Since the beginning of April this year, insisted on three times a week injections of glycolic acid, platelets down to Is this routine blood test result (especially the high level of young granulocytes) a big problem? I would like to get your answer to guide me. Thank you! The patient: Director Fan, because my last routine blood test showed a high level of [IG] juvenile granulocytes 0.7, the attending physician asked me to retest my peripheral blood cell pattern, saying that I should be monitored for transformation into leukemia, and now I am uploading the test result report to you (the report is too professional, I can’t read it). Because I am not skilled in computer operation, I do not know whether the upload is successful or not, so please check it. I hope you can tell me whether the report reflects the situation of “turning white”. Fan Lei, Department of Hematology, Jiangsu Provincial People’s Hospital: From the information you provided, there is no evidence of turning white yet. Patient: Thank you, Director Fan! Every time you reply, it is very timely and pertinent! At a time when the doctor-patient relationship is not very harmonious, it is a blessing for the patient to meet such a warm and responsible doctor like you! Fan Lei, Department of Hematology, Jiangsu Provincial People’s Hospital: It is advisable to review bone marrow aspiration and flow pattern every six months. Patient: Director Fan, I have not been on the Internet for more than a month, and only yesterday I saw your advice to review bone marrow aspiration and flow pattern every six months. Thank you for your advice. In addition to monthly routine blood tests, how often should I have my peripheral blood cells retested? Also, is there a high chance of turning white with hydroxyurea? I’m a newbie to the internet, so I’m not sure if I can do it. I’m just a newbie to the internet, so please bear with me if I don’t succeed. Fan Lei, Department of Hematology, Jiangsu Provincial People’s Hospital: Blood smear can be synchronized with bone marrow examination unless there is a significant abnormality in the blood routine. Although animal tests suggest that hydroxyurea may lead to disease transformation, there is no conclusive evidence in humans, so it can be used.