If the platelet count exceeds 500×10^9/L, it suggests that it is well outside the normal range and requires aggressive treatment and identification of the cause. Normal platelet count is 100×10^9/L-300×10^9/L. A platelet count over 500×10^9/L is well above the highest level of the normal range. Clinical factors that cause increased platelet counts are divided into two main categories: primary and secondary. Primary factors such as primary thrombocytosis; secondary causes such as chronic inflammation, recovery from acute infections, tumors, and iron deficiency anemia can cause platelet increase. When the platelet count increases to 500×10^9/L, it increases the risk of bleeding and thrombosis, and thus patients need to pay attention to it. Patients are advised to consult a hospital in a timely manner to identify the cause and actively treat the condition. Usually pay attention to a light and nutritious diet, avoid spicy and stimulating foods, pay attention to rest and avoid staying up late.