Ankylosing spondylitis is a disease that involves the joints of the spine, sacroiliac joints, and paravertebral ligaments, eventually leading to ankylosis and deformity of the entire spine. In the later stages, bony fusion of the joints and calcification of the ligaments occur, resulting in an ankylosed spine. It is also known as “upward spondylitis” because it starts in the sacroiliac joint and gradually spreads upward. At present, there is no effective cure for spondylitis, so in order to make patients understand the disease properly and prevent it at an early stage. In addition to comprehensive treatment of patients, the implementation of reasonable health education to patients, so that patients to delay the course of the disease, reduce pain, improve the quality of life. The content of health education: 1, psychological care of patients with this disease is a heavy burden on the mind, the nurse should adopt methods such as guidance, encouragement, implication, support, etc., to establish a good nurse-patient relationship, to obtain the trust of patients. According to the patient’s condition, care should be tailored to the individual. Understand the patient’s understanding of the disease and treatment, and understand the patient’s thoughts. According to the characteristics of the patient, educate the patient and family members about psychological care, care and understand the patient, listen patiently to the patient’s questions, and give timely answers. Although this disease is a disabling disease, it is a disease that can be completely controlled after a long course of comprehensive treatment, so we should encourage patients to be psychologically prepared for long-term treatment and establish the idea of perseverance. Explain to the patient the relationship between disease and emotion, depression and bad mood can lead to the slowing down of circulation in all organs of the body, and the decrease of resistance, which can easily cause other diseases. Through the cooperation of doctors and patients to solve the psychological barriers, the correct evaluation of their own disease, to promote the patient’s attitude from negative to positive, from pessimism to optimism, from passive acceptance of treatment to active participation, so that the patient to establish a healthy and upward spirit, with external treatment to gradually improve the disease. 2, prevention of infection due to thoracic involvement prone to lung infection, patients should be encouraged to perform daily chest expansion exercises and deep breathing, patients who are unable to take care of themselves should be turned and patted on the back and encouraged to cough, and nutrition should be supplemented to enhance resistance. The windows of the ward should be opened regularly for ventilation, and ultraviolet light disinfection should be carried out for one hour every day. 3.Medication and diet guidance: Instruct patients to take medication according to medical prescriptions. ( 1) Inform patients of the possible side effects of drugs, observe the effect and reaction of drugs such as non-steroidal anti-inflammatory drugs, which are fast-acting and can control the symptoms in a short time, and can rapidly improve the pain and stiffness of low back, reduce joint swelling and pain, and increase the range of motion of joints, but can cause constipation, hiccups, gastritis, vomiting and other gastrointestinal symptoms, patients should be instructed to take them after meals to reduce the stimulation of the stomach. If the gastrointestinal tract reflects obviously, intra-anal suppositories can be used, and if necessary, gastric mucosal protective agents can be combined. ( 2) chronic-acting drugs such as sulfasalazine, methotrexate, these drugs have a slow onset of action, taking 1 to 3 months to take effect, can slow or stop the development of the disease, with anti-infective immunomodulatory and anti-inflammatory analgesic effect. It can control the disease activity of ankylosing spondylitis, improve joint pain and stiffness, but it usually takes 6-8 weeks for the drug to take effect. Patients should be instructed to take the medication for a long time, and to check blood and liver function during the medication period, and to use with caution in patients with hepatitis B virus. Dietary guidance: Patients are advised to eat a nutritious and easily digestible diet, rich in protein and vitamins, calcium and iron, avoid spicy, fatty, tobacco and alcohol and other stimulating foods, and to maintain a balanced diet. In addition, the diet can also be adjusted from the perspective of Chinese medicine, Chinese medicine believes that the external causes of the disease to wind, cold, damp close relationship, such as onions, pepper, garlic, etc. has the role of anti-wind and cold, appropriate food can prevent viral infections and intestinal infections. Legumes are rich in protein and trace elements, which have the function of promoting the metabolism of muscles, bones, joints and tendons, and helping to repair the disease damage. Chestnuts have the effect of tonifying the kidneys and strengthening the tendons and bones, which is very beneficial to this disease. Plum acid anhydride can astringent yin, acid and liver, liver nourishing, painful spasms of tendons and bones have the effect of relieving pain. 4, functional exercise to maintain the flexibility of the spine: ( 1) deep breathing: every morning, work breaks and before bedtime should routinely do deep breathing exercises, deep breathing can maintain the maximum activity of the thorax; ( 2) cervical exercise: the head and neck can do forward, backward, left, right rotation, as well as head rotation movement, to maintain the normal mobility of the cervical spine; ( 3) lumbar exercise: daily lumbar exercise, forward bending, backward, lateral bending and left and right ( 3) lumbar exercises: daily lumbar exercises, forward bending, backward bending, lateral bending and left and right rotation of the torso, so as to maintain the normal mobility of the lumbar spine; ( 4) limb exercises: can do push-ups, diagonal bracing, lower limb forward bending and backward extension, chest expansion exercises. Patients with mild flexion deformity of the spine and hip joints can perform prone once or twice a day, 15-30 minutes each time, using their own body weight to do antagonistic traction, in order to correct the deformity. If the condition permits, swimming includes both chest expansion and body movement at the appropriate water temperature, and helps to increase lung function and maintain the normal physiological curvature of the spine, which is the most suitable whole-body exercise for ankylosing spondylitis, but diving is strictly prohibited. Running may aggravate the symptoms of ankylosing spondylitis, especially hip involvement is not advocated, after exercise may increase joint pain, if short-term rest can be relieved, it is normal; if the new pain after exercise lasts more than 2 hours or exercise caused by fatigue and discomfort, difficult to recover, it means that excessive exercise should be appropriate to adjust the amount of exercise, type of exercise or suspension for rest. 5, self-care guidance ankylosing spondylitis serious consequences of spinal ankylosis and hip deformity and disability, therefore, in the early stages of the disease and deformity has not formed, before the emergence of bony ankylosis, it should be prevented beforehand. Sponge bed or Simmons bed, its concave, can aggravate the patient’s pain and passive position, and over time there will be scoliosis, hard board bed because of the plane hard, so that the trunk in bed can not be bent, ankylosing spine is physiological position, thus playing a controlling role in preventing spinal deformity, so tell the patient once the disease must sleep on a hard board bed, sleep with a low pillow or no pillow to reduce the cervical forward bending, should avoid strain and wind and cold moisture, Pay attention to reduce the weight of the spine, avoid prolonged bending activities and physical activities that cause pain. To prevent hunchback deformity, patients should be instructed to maintain proper posture, both in the acute and chronic phases, and to stand with chest up, abdomen tucked in and eyes leveled, and to sit with back straightened.