Usually not only depressed people have depressive moods, but normal people also have depressive moods when they are in a bad mood or under stress, but they usually last for a short period of time. In contrast, depressed people usually have depressed mood for a relatively long time and it is more difficult for them to adjust themselves, so they need medication and psychotherapy. Depression in the general population is usually short-lived and can be relieved by self-adjustment due to poor mood and other reasons. In contrast, patients with depression have persistent depressed mood as the main clinical manifestation, and the duration of the disease is generally > 2 weeks, accompanied by insomnia, early awakening, upset and anxiety, reduced interest, low self-esteem, slow thinking, negative pessimism and other symptoms, compared with the depressed mood of the general population, the symptoms are more abundant and last longer, and it is more difficult to self-adjust. In addition, no matter how the depressive mood arises, it is recommended to actively participate in daily exercise, such as swimming, jogging, playing badminton, etc., because exercise can promote the secretion of endorphins in the brain, which helps to alleviate depressive mood. If self-adjustment does not improve, it is recommended to consult a psychiatrist for guidance and, if necessary, to take oral antidepressants such as sertraline hydrochloride tablets and fluoxetine hydrochloride capsules as prescribed by the doctor.