The nine-valent vaccine refers to the nine-valent human papillomavirus vaccine, or nine-valent HPV vaccine, which mainly has the effect of preventing cervical cancer and cervical precancerous lesions. Some women who have not had sex can also get the nine-valent vaccine directly without testing, but this needs to be determined by individual circumstances. It is generally recommended that people who have already experienced sexual intercourse and have a higher chance of HPV infection should try to undergo relevant examinations before the vaccination. Pre-valent HPV vaccine tests usually include HCG early pregnancy test, pelvic ultrasound, routine blood test, urine test, vaginal discharge test, HPV test and cervical fluid cytology test. These tests can help rule out pregnancy, gynecological diseases, HPV infection, etc. in order to determine if the nine-valent HPV vaccine is suitable for: 1. Pregnant women: If a woman is in pregnancy, nine-valent HPV vaccination is usually not recommended. If a woman is pregnant during the period of nine-valent HPV vaccination, she can be vaccinated after the pregnancy period is over. 2. Women with gynecological diseases: If there are chronic inflammatory diseases in the pelvis, such as pelvic inflammatory disease, cervicitis, vaginitis, etc., or patients with other gynecological diseases, such as polycystic ovary syndrome, etc., they usually need to be treated for gynecological diseases before receiving the nine-valent HPV vaccine. If there is a need for vaccination, you can explain the situation to your doctor and change the vaccine type under the guidance of your doctor, or get vaccinated after your condition is under control; 3. Women with HPV infection: Generally speaking, if you have low-risk HPV infection, it does not affect the nine-valent vaccination. However, if you have high-risk HPV infection, such as HPV-33, HPV-51, etc., you need to wait for the virus infection to turn negative after treatment with interferon and other drugs before vaccination. HPV is mainly transmitted through sexual intercourse, so people who have not experienced sexual intercourse and maintain good lifestyle habits may not be tested before getting the nine-valent vaccine. However, chronic uterine disease, cervical disease, and long-term habits such as smoking and drinking may also trigger HPV infection, so it is recommended that you undergo relevant tests before getting the nine-valent vaccine. The nine-valent vaccine does not have a therapeutic effect on HPV infection, and it is not very meaningful for patients who have already developed cervical cancer lesions to receive the nine-valent vaccine again. Therefore, it is recommended that people with high-risk factors for HPV infection should undergo cervical cancer-related tests and determine whether they can be vaccinated based on the test results and guidance from the staff at the vaccination site.