In recent years, biologics such as etanercept, infliximab and adalimumab have been gradually promoted. In addition to the well-known “expensive”, there is a general concern about the side effects and effectiveness. Space is limited, shallowly discussed as follows. 1, expensive. Adequate use of biological agents, the monthly cost ranges from 3000-8000 yuan. Because it is not a “national essential drug”, the price is not uniform, the same species in different hospitals (pharmacies) prices may be different, the maximum difference in annual drug costs can be up to 10,000 yuan. Therefore, on the basis of choosing a trustworthy hospital, you should spend less money as possible. 2. Side effects. The “safe use of drugs” is more important than the “effective use of drugs”. The most concerned and well-known side effect of biologics is “reducing human resistance”. For example, patients with chronic diseases such as hepatitis and tuberculosis may have recurrent illness after prolonged use of the drug (so consider using prophylactic anti-tuberculosis or antiviral treatment). In addition, there is also a side effect that has received less attention but has been “talked about”: tumors. In the 17 years since its introduction, there has been data showing an increased risk of malignant lymphoma and cutaneous melanoma in cases using biologics (although the chances are low). However, it is important to look at the tumor issue holistically: patients with rheumatic diseases are inherently susceptible to these tumors due to their own immune dysfunctions. In addition, other drugs, including methotrexate and leflunomide, as well as some of the complex pharmacological components of traditional Chinese medicine, can induce tumors. The residual pesticides, heavy metals and chemicals that are difficult to eradicate during the planting and processing of medicinal herbs can also induce tumors. All medicines are toxic, but do not exaggerate. Reduced exercise due to medical condition, poor appetite, poor rest, poor mood, pessimism and depression, and overthinking may also cause low resistance and tumor. Other side effects, such as heart function in heart failure, demyelinating lesions, and the lengthy description of side effects observed in the instructions, are a reflection of scientific rigor, and most occur at low and mild rates, so there is no need to be overly concerned. All drugs are toxic in three ways. In comparison, biologics, Chinese medicine and Western medicine all have their own side effects. If used properly, the side effects of biological agents are not greater than those of drugs. For side effects, we should do a good job “to avoid, prevent, control and cure”, and plan ahead. 3, how effective. ”Biological agents are good” is a common and vague understanding, and some people simply think that “biological agents are better than taking drugs, imported than domestic, expensive than cheap”, but the problem is not so simple. First of all, different biological agents have their own “most suitable disease”, just as each rheumatologist has his best disease. Secondly, due to economic conditions, different physical conditions, distance, work, life and study, and many other factors, there are a variety of drug regimens, and the regimen is directly related to the efficacy, to find the “best program”. In addition, some people have good effect, some have poor effect or even ineffective, some have stable effect, some have repeated effect, physicians must analyze comprehensively and improve foresight in advance. Summary: Because biologics are expensive, it is more important to consider the side effects and the effectiveness of biologics in a comprehensive manner. The physician should analyze, judge and predict comprehensively before using the medication, and the patient should be outspoken and communicate fully to develop the appropriate medication and program. During the course of medication, we should make timely adjustments, plan ahead, “avoid, prevent, control, and treat” side effects, communicate closely, and do a good job of post-medication management, so as to avoid “taking the medicine with a stroke of a pen and leaving.