What is the concept of “hepatitis B virus carrier”?

  ”Hepatitis B virus carrier” is a very vague concept, many lay people are not able to explain, what is the so-called “carrier”? It is very important to explain this concept clearly to everyone.  The most common route of hepatitis B infection in China in the past was mother-to-child transmission, which was a major route of infection because there was no scientific knowledge of mother-to-child transmission of hepatitis B in the past, and there was no effective method of interruption, but it was by no means the only route of transmission, as hepatitis B can also be transmitted through blood transfusion, sexual transmission and other close contacts.  Most people infected with the hepatitis B virus before the age of 5 become chronically infected, and most infections after the age of 5 have an acute course and then resolve themselves.  If the hepatitis B virus is latent in the body for a long period of time, the patient becomes chronically infected with the hepatitis B virus. A small percentage of these patients have liver damage, or chronic hepatitis B. A large percentage of these patients do not have clear liver inflammation and are so-called “carriers”.  There are two types of carriers: ① “chronic hepatitis B virus carriers” – normal liver function, normal imaging (including ultrasound, CT, MRI, etc.), but positive HBV-DNA (hepatitis B virus ribonucleic acid) test (greater than This condition is named “chronic hepatitis B virus carrier”, which is infectious and potentially dangerous because it carries the virus, often at high levels, and may progress unnoticed.  ② “Chronic hepatitis B surface antigen carriers” – with normal liver function, normal imaging tests (including ultrasound, CT, MRI, etc.), and a negative HBV-DNA (hepatitis B virus ribonucleic acid) test (below the minimum detectable value). This condition is called “chronic hepatitis B surface antigen carrier”, which is not contagious because it is negative for hepatitis B virus, and at the same time, it is less potentially dangerous and relatively stable.  The status of chronic hepatitis B virus infection is dynamic, not static, and can vary between “chronic hepatitis B virus carrier”, “chronic hepatitis B surface antigen carrier”, and “chronic hepatitis B”. Hepatitis B”.  Therefore, patients need to be reviewed and tested regularly to clarify the different states they are in.  2, different states of transition by the age, diet, life, emotions and other factors, resulting in different immune status, resulting in different disease status.  3, neither paralysis, nor excessive tension. In the “carrier” status, no matter what kind of “carrier” means that the liver is not inflammatory activity, that is, the disease is in a relatively stable state, so there is no need to be overly nervous and seek excessive treatment. The company is also not to rest on its laurels, thus neglecting the regular monitoring of the disease.  The first reason is that there is no effective treatment for carriers, and there is no effective way to turn “carriers” into “non-carriers”. Secondly, the use of antiviral treatment for carriers is not effective and may even cause secondary drug resistance and other adverse consequences, so it is likely to be worse than no treatment at all.  5. For carriers, it is recommended to have a systematic review at least once every six months, which includes: five items of hepatitis B, HBV-DNA quantification, alpha-fetoprotein, liver function, blood routine, and ultrasound. It is highly recommended to go to a specialist hospital and use sensitive reagents for standardized examination.  This article is authorized by Dr. Yang Huasheng.