Every disease has a reason, and cancer is also very common in our life. Gallbladder cancer is one of them, and once the disease is contracted, it will seriously affect the healthy life of patients. Let’s learn more about it below. 1.Cholangitis promotes carcinogenesis mostly occurs through the gradual proliferation of gallbladder mucosa. Some studies show that the inflammatory state of gallbladder is induced by implanting cholesterol pills in the gallbladder of pale rats, and 68% of pale rats develop gallbladder adenocarcinoma. Logistic regression model analysis shows that the incidence of gallbladder cancer is 7 times higher in patients with gallbladder stones than in those without stones. Domestic studies show that 20% to 86.6% of gallbladder cancer patients are combined with gallbladder stones, while foreign reports are as high as 54.3% to 100%. 3.Benign gallbladder tumors can be divided into epithelial tumors, mesenchymal tumors and pseudotumors. Among them, gallbladder adenoma and adenomatous hyperplasia are most closely related to gallbladder cancer and are more recognized as precancerous lesions of gallbladder. 4. Impotence of gallbladder, congenital bile duct dilatation and abnormal pancreaticobiliary duct cohesion are closely related to the occurrence of gallbladder cancer. Studies have shown that the incidence of gallbladder cancer is 25% in the case of abnormal pancreaticobiliary ducts, and 1.9% in the case of normal confluence.