The rash of second-stage syphilis may include maculopapular rash (rose rash), maculopapular rash, papular rash, papulosquamous syphilis rash, follicular rash, pustular rash, etc. 1. Maculopapular rash is the earliest skin damage of second-stage syphilis, occurring 5 to 8 weeks after the appearance of hard chancre, commonly on the trunk, shoulders and flexors of the extremities. It is the most common lesion of the second stage of syphilis, which is round or oval, 0.5 to 1cm in diameter and rose-colored. It often occurs 2 to 4 months after infection, and the rash is distributed all over the body, including the face, trunk, and flexors of the extremities. 3. Papules, which are also the most common and characteristic rash of second-stage syphilis, are less numerous than macules and are copper-red in color. The papules can be flat or spiky at the top, varying in size, with smooth or scaly surfaces, widely distributed on the trunk, upper and lower extremities, palmoplants and face. It can be isolated or clustered, forming a ring or bow-shaped damage.4. Pustular rash, which is uncommon, forms pustules after necrosis of macules or papules.