Girls can find dehydroepiandrosterone (DHEA) and its sulfate in urine from the age of 6 to 9, and it rises rapidly from the age of 10, which is the first manifestation of adrenal function. The onset of menstruation is delayed. This stage before menarche is not seen menstruation is a physiological phenomenon, some girls in the first half of the year after the menarche still have a few months of menstruation once, and for anovulatory menstruation is also normal. So, why does prepubertal amenorrhea occur? The following is a brief description of the causes of prepubertal amenorrhea: There are physiological and pathological amenorrhea. The cessation of menstruation before puberty, during pregnancy, during lactation, and after menopause is considered physiological amenorrhea. This discussion is only about pathological amenorrhea. Menstruation is formed by the cyclic regulation of the hypothalamic-pituitary-ovarian axis causing the endometrial cycle to shed, therefore any organic or functional changes in the hypothalamus, pituitary gland, ovaries and various parts of the reproductive tract, especially the uterus, may cause amenorrhea. Organic and functional abnormalities of other endocrine glands may also affect menstruation and lead to amenorrhea.
The organs involved in menstruation include the uterus, ovaries, pituitary gland and hypothalamus, and amenorrhea may occur if any one of them is impaired. Depending on the location of the disorder, there are four types: uterine, ovarian, pituitary and hypothalamic.