Many people at work have expressed to me the fear of having a child that is genetically transmitted. I hope this short article will help to clear the clouds of doubt and dispel concerns. 1. AS is not 100% hereditary, which explains the confusion that some people have about why their parents do not have the disease but they do. Different races, ethnicities, genotypes, genetic phenotypes, regions, and environments all have an impact on the chance of inheritance, so no doctor can tell you exactly “what the chance of inheritance is”. According to the data available in my office and my general statistics, the chance of passing on ankylosing spondylitis to the next generation is about 10%. It is possible that the “hereditary rate” that you see and hear about on a daily basis is even lower than my data, because some people have very mild symptoms and are not seen as having no disease. 2, “genetic factors” is a congenital condition, but the development of most rheumatic immune diseases (including AS) also requires the cooperation of many acquired conditions, such as infectious factors, poor hygiene habits, trauma, endocrine, metabolic disorders and metabolic reactions. Among the many factors, there is no definite conclusion as to which one is the main factor, but the more certain and important factor is infection, including urinary tract infection and intestinal infection. Among patients with AS induced by urinary tract infections, some have prostatitis and a small percentage will have kidney damage. It is also possible to reduce the incidence of AS by paying attention to personal hygiene and health care and reducing urinary tract infections and intestinal infections, which can be done practically. 3. What if my child does get sick? As patients, we are aware of the disease and have the knowledge and alertness to detect the disease early without delaying the diagnosis, and “early detection and treatment” is the nemesis of AS. More importantly, medical development is fast, there will certainly be better drugs, and the existing drugs, including biological agents will certainly gradually reduce the price (once there are better drugs, the current price of biological agents will jump), the national health insurance policy will be more and more perfect, people with serious conditions can certainly get better medical treatment, the disease will shed the veil of the devil, into an easy to clean up the goblin. In fact, our situation today, compared to the situation 10 years ago, is already much improved. 4. In fact, the vast majority of chronic diseases, such as hypertension, diabetes, stroke, gout, various rheumatic diseases, and even many malignant tumors, have a genetic predisposition (i.e., the offspring are more likely to get the disease than the average person). Since ancient times, these people have given birth to children and grandchildren. Various chronic diseases accompany human evolution and development, is a normal phenomenon of human society, “fear of heredity and not born”, is to choke on it. 5, do not blindly believe in the “genetic determinism”. It is well known that B27 is related to AS genetics, but there are many types of B27 (such as B2701, B2702, B2703, etc.), some of which contribute to human morbidity, while others protect the human body from morbidity. In addition to the B27 gene, hundreds of genes/genetic loci have been identified in humans that may be related to AS, but the relevance is not strong and the utility is low and has not been practical so far. Just treat it with a common sense approach, no need to get into the thick of it. For more information on genes and genetics, please refer to my co-editor, Spondyloarthritis and Ankylosing Spondylitis (Science Press), which is covered in tens of thousands of words in Chapters 2 and 3 of Part II.