The onset of gallbladder cancer is relatively insidious, and there are often no obvious fixed symptoms and signs in the early stage, so it is easy to be ignored clinically, and it is already in the late stage when the symptoms are obvious. The main symptoms include right upper abdominal pain, discomfort, belching, loss of appetite, weight loss, low fever and abdominal mass, which are similar to the symptoms of chronic cholecystitis and cholelithiasis. Progressive obstructive jaundice is the main symptom of cholangiocarcinoma, often accompanied by itchy skin, red tea-like urine or clay stools. Patients often have epigastric pain, loss of appetite, weight loss, and sometimes symptoms of acute cholangitis such as chills, fever, nausea, vomiting, etc. When the cancer is located in the common bile duct, patients often have gallbladder enlargement, while those with cancer above the bile duct often do not have gallbladder enlargement, but the liver is always enlarged due to bile accumulation.