The genetic inheritance of thalassemia The rate of carrying the gene for thalassemia in Guangdong is as high as 12%, so Cantonese people must get married and have prenatal checkups. The genetic inheritance of thalassemia is autosomal, and the condition of thalassemia is related to the heterozygosity of the disease gene, if it is a pure heterozygote, the condition is more serious and most people cannot survive for a long time, while heterozygotes have a mild condition and can grow and develop, so most of the thalassemia patients who can get married and have children are mild patients. Firstly, if both men and women are heterozygous, i.e., both are mildly affected, then there are three possible cases of their children: (1) normal, with a chance of 1/4, (2) severely affected, with a chance of 1/4, and (3) mildly affected, with a chance of 1/2. Secondly, if one side is normal and one side is mildly affected, then there are two possibilities of children: (1) normal and (2) mildly affected, with a chance of 50%. In the case of a child with a child with a type and degree of geodystrophy similar to that of the father or mother, the chance is 50%.