Glutamyl transpeptidase is found mainly in tissues such as kidney, pancreas, liver, spleen, intestines, brain, lungs, skeletal and cardiac muscles. Whereas serum glutamyl transpeptidase is mainly derived from the hepatobiliary system, glutamyl transpeptidase in the liver is mainly distributed in the epithelial cells within the bile ducts and in the endoplasmic reticulum of the smooth surface of hepatocytes. The normal range for glutamyl transpeptidase is 0-40 U/L, and higher than 60 U/L suggests abnormality. When glutamyltransferase rapidly reaches 146 U/L, it has more than doubled the normal value. At this point, the situation is relatively serious and the specific cause should be clarified based on clinical symptoms as well as further ancillary tests. There are many causes of glutamyl transpeptidase, and diseases of the hepatobiliary system, such as hepatocellular carcinoma, obstructive jaundice, biliary cirrhosis, cholangitis, infectious hepatitis, cirrhosis, etc., should be considered first. In addition, long-term alcohol consumption or ethanol poisoning can also cause elevation of glutamyl transpeptidase. Diseases outside the hepatobiliary system, such as acute pancreatitis, diabetes and myocardial infarction, may also cause elevated values of glutamyl transpeptidase. In daily life, it is recommended to abstain from alcohol, low cholesterol diet; control weight, reasonable exercise, strengthen sports, etc.. If the index continues to rise, other causes should also be analyzed, and if necessary, go to the hospital for systematic examination.