The treatment of depression is a long-term and arduous process, and many patients may still have some residual symptoms to a greater or lesser extent after a period of treatment, mainly including: 1. Fatigue: 73%-96% of depressed patients will be accompanied by a sense of fatigue. In addition, fatigue is a more common residual symptom in the process of antidepressant treatment. 2, anxiety: depression with anxiety is very common in clinical practice, about more than 62% of depressed patients with anxiety. Anxiety can be present throughout the course of the disease. Therefore, anxiety is considered to be one of the more important residual symptoms of depression. And the presence of anxiety is often considered a problem with the efficacy of the antidepressant for patients. 3, sexual dysfunction: the appearance of sexual dysfunction in patients with depression is a common phenomenon, studies have shown that: 53% of patients in partial remission after treatment showed moderate sexual dysfunction and 26% showed mild sexual dysfunction. 4, sleep disorders: sleep disorders often have is not the risk of depression. Persistent sleep disorders may signal chronicity of the disease and affect the patient’s quality of life, increasing the chances of disease recurrence. The prognostic impact of the presence of residual symptoms is multifaceted, such as relapse, relapse of combustion, impairment of work ability, and pessimistic mood. Patients with major depressive disorder who have residual symptoms are more likely to relapse than those who recover after treatment. 76% of patients with residual symptoms relapse within 10 months of treatment, while only 25% of patients without residual symptoms relapse within the same time frame. Therefore, it is important to treat residual symptoms to reduce the chance of recurrence.