Among the malignant tumors of gallbladder, gallbladder cancer takes the first place, and other tumors include sarcoma, carcinoid tumor, primary malignant melanoma and giant cell adenocarcinoma. Primary gallbladder cancer is clinically rare and only accounts for about 1% of all cancers according to domestic reports. 1.Surgical treatment It can be done by resection of cholangiocarcinoma of the hilar part, palliative surgery of cholangiocarcinoma of the hilar part, resection of cholangiocarcinoma of the lower and middle parts of the liver. 2.Chemotherapy Intraoperative intubation to hepatic artery through gastroretinal artery, after leaving drug pump under the skin, drug is administered through drug pump, commonly used chemotherapy drugs are 5-Fu, MMC. 3.Radiotherapy Intraoperative radiotherapy, postoperative localization radiotherapy and intra-stage irradiation, etc. Radical radiotherapy dose irradiation has certain effect on advanced cholangiocarcinoma, which can make cancer cells degenerate and necrosis and inhibit their growth, which can prolong the survival of advanced cholangiocarcinoma patients.