Ms. Li, 58 years old, was found to have gallbladder stones by ultrasound during her physical examination 3 years ago, but had no obvious symptoms at that time. Three months ago, he was admitted to the gastroenterology department of our hospital with a diagnosis of “acute pancreatitis, common bile duct stones and gallbladder stones”. He was transferred to the Department of Lumpectomy for laparoscopic cholecystectomy and was discharged three days after the operation. The pancreatitis, common bile duct stones and gallbladder stones were cured at this point. When she was discharged from the hospital, Ms. Li lamented, “She turned one disease into three diseases and was hospitalized for more than a month, spending nearly 50,000 yuan, all because of gallbladder stones.” So, what are the possible scourges of gallbladder stones? Biliary colic: If the stone is stuck in the neck of gallbladder or gallbladder duct, the bile in the gallbladder cannot flow out, the pressure in the gallbladder rises, the gallbladder expands, and the gallbladder contracts strongly to allow the bile to be discharged. The rapid expansion and contraction of the gallbladder in a short period of time produces severe colic. Gallbladder inflammation: Patients with gallbladder stones have chronic inflammation of the gallbladder; if the pressure in the gallbladder increases and secondary bacterial infection occurs, it causes acute cholecystitis and pus accumulation in the gallbladder. If the blood supply is obstructed, it can cause serious injuries such as necrosis and perforation of the cyst wall, peribiliary abscess, diffuse peritonitis, gallbladder-enterogastric fistula. Bile duct stones: small stones or bile sludge draining into the common bile duct via the cystic duct, causing secondary bile duct stones, which may further lead to common bile duct obstruction (producing jaundice), inflammatory stricture of the lower end of the common bile duct or purulent cholangitis. Pancreatitis: Acute pancreatitis may occur when gallbladder stones cause spasm of the sphincter of Oddi or when secondary common bile duct stones lead to obstruction of the common bile duct and pancreatic duct. Most acute pancreatitis in China is associated with gallbladder stones. Liver damage: When gallbladder stones are accompanied by cholecystitis, inflammation can directly invade liver tissue; bacteria in the gallbladder spread to the liver via small veins in the gallbladder bed and lymphatic system; larger stones in the gallbladder are embedded in the neck of the gallbladder or embedded in the mouth of the gallbladder duct, blocking or compressing the extrahepatic bile duct and causing liver damage by obstruction of the bile duct. Cholelithiasis is the most common cause of bacterial liver abscess. Gallbladder cancer: Some data show that about 37% to 75% of gallbladder cancer patients are accompanied by gallbladder stones, and 0.3% to 1.5% of gallbladder stones are complicated by gallbladder cancer, which proves that gallbladder cancer is directly related to gallstones. The mechanism of gallbladder cancer may be related to the long-term mechanical irritation of gallbladder stones and recurrent inflammation of gallbladder.