Gallbladder stones are mainly seen in adults, more in women than men, and their incidence increases with age after the age of 40. The stones are cholesterol stones or cholesterol-based mixed stones and black bile pigment stones. The harm of gallbladder stones is mainly manifested in the following 7 aspects: 1. Biliary colic: The typical attack is when the gallbladder contracts or stones are displaced after a full meal, eating greasy food or when the position changes during sleep. The pain is located in the right upper abdomen or epigastrium and is paroxysmal, or the pain is continuously increasing in paroxysms and may radiate to the right shoulder and foot and back. After the first occurrence of biliary colic, about 70% of patients will have another attack within a year. 2, epigastric vague pain: most patients only feel vague pain in the upper abdomen or right upper abdomen when they eat too much food, fatty food, work tension or poor rest, or have fullness and discomfort, warmth, rebellion, etc., which is often misdiagnosed as “stomach disease”. Small stones can enter and stay in the common bile duct through the cystic duct and become common bile duct stones; 4. Stones entering the common bile duct through the sphincter of Oddi can cause injury or become lodged in the abdomen and lead to pancreatitis, which is called biliary pancreatitis. 5.The long-term stimulation of stones and inflammation can induce gallbladder cancer. Gallbladder effusion: When gallbladder stones are embedded for a long time or obstruct the gallbladder duct but not combined with infection, the gallbladder mucosa absorbs bile pigments in bile and secretes mucus substances, resulting in gallbladder effusion. The accumulated fluid is transparent and colorless, called white bile. 7, due to stone compression caused by inflammation of the gallbladder chronic perforation, can cause gallbladder duodenal fistula or gallbladder colonic fistula, large stones through the fistula into the intestine can occasionally cause intestinal obstruction, known as gallstone intestinal obstruction; in clinical work, the first four hazards are the most common, the last three are relatively rare.