No! In 1867, Bobbs, an American, first reported the surgical treatment of gallbladder stones by cutting open the gallbladder, removing the stones, and then closing the gallbladder incision. This was a major advance in the history of gallbladder stone treatment. Later, it was found that the recurrence rate of gallbladder stones in patients treated with this method was high. In 1882, German Langenbuch carried out the first successful cholecystectomy for gallbladder stones, which led to a complete cure of gallbladder stones, and for more than 100 years, cholecystectomy has become the gold standard for the treatment of gallbladder stones. Especially after the introduction of laparoscopic cholecystectomy in 1987, it has made gallbladder removal easier, more minimally invasive and more acceptable to patients. For this reason, more and more people are undergoing cholecystectomy for gallbladder stones. Whether gallbladder stones must be removed from the gallbladder is controversial within the academic community. Some people believe that stones in the gallbladder are not simply foreign bodies, but stone disease, and that stones are accompanied by a gallbladder that produces stones, so they advocate removing the gallbladder together; others believe that the gallbladder has important physiological functions, and that a normal functioning gallbladder can be preserved after simple lithotomy, and that the recurrence rate of stones after lithotomy is not as high as reported in the past. The mechanism of gallbladder stone formation is not well understood, but two points are clear, namely abnormal bile composition and abnormal gallbladder function. The abnormalities of bile composition depend on the altered physiopathology of the whole body. For example, people with 3 F’s (female, fourty, fat female, 40 years old, obese) are prone to cholesterol supersaturation in their bile and are prone to stone formation. Bad habits such as partial diet, irregular diet, lack of physical exercise, and excessive smoking can also lead to abnormal bile composition and easy formation of stones. However, as the living environment and habits improve and other diseases of the body improve or are cured, the abnormalities of bile will also improve. This is illustrated by the fact that some gallbladder stones are stable for years or decades without change after initial rapid growth. There is a clear difference between the current cholecystotomy and Bobbs’ method of more than 100 years ago, which was to remove the gallbladder blindly with a lithotripter after the gallbladder was incised. The thread cannot be absorbed and can become the core of stone re-formation. The modern method of stone extraction is to “fish out” the stones with a mesh under direct vision of fiberoptic choledochoscope, and the stones are removed completely and thoroughly. In the case of asymptomatic gallbladder stones, there is no need to remove the gallbladder. Please note the following data: asymptomatic gallbladder stones account for 20-40% (about 1/3) of gallbladder stones. Many patients are found to have stones at the time of a health check. Asymptomatic gallbladder stones become symptomatic in 20-30% of cases within 20 years of detection. Complicating stones (bile duct stones, pancreatitis, etc.) rarely occur in asymptomatic gallbladder stones before they turn into symptomatic gallbladder stones. Therefore, cholecystectomy is considered for asymptomatic gallbladder stones only in the following cases: 1. in combination with cholecystitis, gallbladder polyps and poor gallbladder function; 2. in combination with gallbladder cancer; 3. in combination with gallbladder calcification (porcelain vase gallbladder); 4. in combination with large stones (>2.5 cm); 5. in pediatric patients; 6. in combination with diabetes or cardiovascular disease. When non-surgical treatment is chosen, asymptomatic gallbladder stones can be treated without any treatment.