Glioma is difficult to cure surgically because of its biological characteristics of infiltrative growth. Some data show that: when the tumor cell count is 1010, its weight is 10 grams and the diameter is 2.72cm as shown by CT; when the tumor cell count is 1011, its weight is 100 grams and the diameter is 5.85cm; when the tumor cell count is below 108, it cannot be detected by the naked eye, at this time, the tumor cell count can be decreased up to 106 level by means of radiotherapy, etc. When the tumor cell count is less than 104, the When the tumor cell count is less than 104, the body’s own immune mechanism can clear the residual tumor cells to obtain cure, so the degree of surgical resection of tumor is directly related to the patient’s prognosis. For tumors located in non-functional areas, the resection can be expanded within a certain range; while in the central area, the imaging iso-volume resection of tumors is its maximum limit. Most of the gliomas located in the central region of the brain cause clinical symptoms such as hemiparesis, hemianesthesia and epilepsy. In the past, most of the tumors were located by freehand according to imaging data or by using framed stereotactic instruments, but because some of the tumors are difficult to identify their boundaries with the naked eye or microscope, making both methods easy to lose their direction during resection. Blind exploration is likely to cause damage to the structures around the lesion, resulting in aggravation of postoperative motor or sensory impairment and unsatisfactory resection. The application of neuronavigation system in glioma surgery in the central brain area has the following advantages: 1. Accurately determine the location of the lesion, sensory and motor function areas, select the appropriate access, avoid cutting the central anterior gyrus and posterior gyrus of the cortex, and reduce the damage to important functional areas; 2. 3. Real-time positioning, dynamic tracing, and observation of the extent of lesion removal at any time; 4. The fine operation of microsurgery can undoubtedly reduce the damage to the nerve fiber bundle. In this group, two cases failed to achieve total resection by imaging, and three cases showed short-term aggravation of neurological dysfunction. The short-term exacerbation of symptoms may be related to brain tissue edema, but the results still suggest the presence of neuronavigation system errors. And brain drift is the most critical factor affecting the accuracy of neuronavigation. Since the current neuronavigation system uses imaging data from the patient’s preoperative period rather than real-time acquisition, brain tissue drift is inevitable as the surgery proceeds, under the influence of many factors such as partial resection of the lesion, cerebrospinal fluid outflow, body position, and brain edema around the lesion. The following points should be noted to reduce the errors caused by brain tissue drift: 1. Mark the tumor boundary in advance, place micro-diameter silicone tubes around the tumor to the bottom of the tumor under the guidance of navigation, make a “fence” around the tumor, and remove the tumor according to the guidance of silicone tubes; 2. Place the cranial site at the highest point to keep the surgical path at a vertical angle, so as to For glioblastoma on the medial side of the brain, the lateral position with the side of the lesion on top is used; 3. The use of CUSA can better meet the requirements of in situ resection.