Preface: More and more couples are experiencing infertility, part of which is attributed to men, who often go to see male infertility at this time, so do you know what details to pay attention to when looking at male infertility? What do you need to explain to the doctor? Here’s what you need to know. What are the abnormalities that should be highlighted to the doctor? The following abnormalities should be highlighted to the doctor as they are high-risk factors that may affect male fertility: history of pubertal development: past history of acute mumps, testicular descent and abnormal development; history of testicular injury: scrotal swelling and pain after severe perineal trauma, open scrotal injury; history of surgical procedures: hernia surgery, testicular surgery, varicocele surgery and pelvic spine surgery; drug or History of drug exposure: antineoplastic drugs, hormones, some herbal medicines; History of genitourinary infections: severe urethritis, gonorrheal urethritis or epididymitis, epididymitis/testoiditis, etc.; Systemic diseases affecting fertility: e.g. liver and kidney dysfunction, endocrine disorders, malignancies; Occupational environmental factors affecting fertility: ionizing radiation, microwaves, radiation, heavy metals; Severe sexual dysfunction: erectile dysfunction, premature ejaculation, inability to complete intravaginal ejaculation; family genetic history: consanguineous marriage of parents, infertility of relatives in the family, especially siblings; visceral inversion, olfactory deficiency and susceptibility to upper respiratory tract infections. Which infertility cases should be considered with the help of assisted reproductive technology? Assisted reproductive technology is a type of technology that involves human intervention in the reproductive process through medical means. Commonly used techniques include artificial insemination with husband sperm, artificial insemination with donor sperm, in vitro fertilization (commonly known as IVF) and single sperm intracytoplasmic injection. There are strict medical indications for receiving assisted reproductive technology treatment, which should be decided by a reproductive medicine specialist based on the specific condition. However, the following cases should be considered for assisted reproduction technology: 1. primary infertility for more than 4 years, even if no obvious cause is found in the examination of both parties; 2. male semen quality continues to be seriously low after treatment (drugs or surgery) is ineffective; 3. both men and women have some degree of abnormalities, such as decreased semen quality in the male partner and abnormal follicle development and tubal obstruction in the female partner, and are unable to conceive naturally for a long time; 4, The male partner has no sperm in the semen or severe oligospermia; 5. The female partner has follicular dysplasia or severe tubal adhesion obstruction; 6. The spouse is older, such as over 34 years old. The basic procedure of in vitro fertilization consultation: both men and women should go to the male infertility clinic and female infertility clinic of the fertility center respectively, bring along their previous examination records and reports of relevant examinations, and be examined by both doctors to determine the need for in vitro fertilization assisted reproduction, and write a special medical record for assisted reproduction technology after determining the program and building a file; examination: including semen analysis of the male partner (routine and morphology, results valid in March), sperm DNA, and sperm DNA. The examination: including semen analysis (routine and morphology, results valid within three months), sperm DNA fragmentation, sperm acrosome enzyme function, liver and kidney function, blood and urine routine, serological examination of infectious diseases (such as AIDS, syphilis, hepatitis B, hepatitis C, etc., results valid within six months), chromosome G-band analysis, etc. for the male partner. The female partner except semen, the same tests as the male partner, and records of gynecological (infertility) examination and consultation (such as ultrasound, sex hormones, imaging of reproductive ducts, hysteroscopy records, hysteroscopy records, etc.), etc.; Archiving: The doctor of the fertility center will make an appointment to arrange for the couple to come to the fertility center for archiving according to the progress of the disease and treatment. The couple must sign the informed consent form and bring all the above documents and three certificates (ID card of both parties, valid marriage certificate, and birth certificate issued by the family planning department of the household registration); undergo fertility treatment: according to the condition, they will receive treatment such as down regulation, ovulation promotion and follicle monitoring, egg retrieval, sperm retrieval, in vitro fertilization, embryo culture, transfer, pregnancy monitoring, etc.