Starzl, the originator of liver transplantation, predicted that the future of transplantation surgery would monopolize the entire operating room, increasingly highlighted by the increasing number of patients awaiting transplantation and the shortage of donor livers. With the maturation of liver transplantation technology and the improvement of transplantation immunology, liver transplantation has become an effective treatment for end-stage liver disease and has now entered a mature stage, with widely recognized clinical efficacy and expanding indications for liver transplantation. The indications for liver transplantation are also expanding, including the age restriction of patients. What is the appropriate age for liver transplantation? In the early days of liver transplantation, most patients were restricted to be within 50 years of age because of immature surgical techniques, insufficient anesthesia experience, lack of experience in perioperative management, etc. Nowadays, most people believe that being over 75 years old is not a contraindication to liver transplantation, mainly due to the following factors: First, the level of liver transplantation technology has improved: since the first clinical liver transplantation in 1963, there have been several decades of hard work. The perfection and progress of anesthesia has laid the foundation for the further development of surgery, and perfect anesthesia surgery is necessary to do well in complex surgery; 2. The perfection of surgical techniques has greatly reduced the operating time and surgery-related complications; 3. The maturity of perioperative management experience has not only greatly reduced the incidence of complications, but also greatly increased the cure rate even after individual complications have occurred. Secondly, physical strength: With the progress of society and the improvement of living standard, the physical quality of the people is also improving. In the past, the physical strength of 75 years old may not be able to withstand the slightest blow, but now the physical strength can still withstand the baptism of “wind and rain”, therefore, the surgery that was not suitable before can be done now. Third, the concept of change: most people used to think that 75 years old is already very old and may give up treatment when they have a major disease, but now most people will do their best to fight for a ray of hope, which is a response to people’s cherishing of life. Fourth, medical assessment is perfect: under the existing medical conditions, a detailed examination and assessment must be done to determine whether a senior patient is suitable for surgery, including the functional assessment of the heart, lungs, kidneys and other major organs, after which the functional reserve of each major organ is still good, that is, suitable for surgery. Fifth, the level of comprehensive medical care has improved: some patients may have given up on surgery in the past because they were temporarily unsuitable after examination, but with the improvement of modern comprehensive medical care, patients who were previously unsuitable may be transformed into patients suitable for surgery after treatment. Sixth, the information network helps a lot: In today’s highly developed information network, everyone can keep abreast of the cutting-edge developments, fully translate and apply the technological progress to the front line, and assist in solving some complex problems through network communication. In summary, being over 75 years old is not a contraindication to liver transplantation. In my medical career, I have had a successful case of liver transplantation for a 75-year-old patient with end-stage cirrhosis, who is now over 80 years old and is able to take care of himself in terms of diet and living.