Glioblastoma, a common malignant tumor of the nervous system, is very malignant and progresses rapidly, some of which may even cause death within a week to two weeks. Of course, some patients may survive for several years if they are treated aggressively. At present, there is still a lack of knowledge about this kind of tumor. The current treatment is mainly a combination of surgery, radiotherapy and chemotherapy. However, it must be judged on a case-by-case basis. First of all, surgery is recommended for glioblastoma, regardless of the size and severity of the disease. However, there are certain principles for surgery, that is, to remove as much tumor as possible without aggravating neurological dysfunction, firstly, to remove tumor tissue, secondly, to achieve effective intracranial decompression, and thirdly, to reduce cerebral edema and neurological complications, so as to lay a good foundation for later treatment. The third is to reduce cerebral edema and neurological complications, which is a good foundation for the later treatment. Also, the decision of whether to perform further radiotherapy, chemotherapy or even bioimmunotherapy must be made according to the specific pathology type after surgery, and the specific plan is determined by different pathology types. Moreover, each form of tumor has different sensitivity to radiotherapy and chemotherapy, so post-operative pathology is very necessary. Of course, if puncture biopsy treatment is performed before craniotomy, it can also clarify the pathological nature, and for some tumors with important functions going to the preoperative radiotherapy as well as chemotherapy measures can increase the survival rate.