Although the incidence rate of gallbladder cancer is much lower than that of liver cancer and pancreatic cancer, the prognosis of gallbladder cancer is comparable to or even worse than these two types of cancer, because patients with gallbladder cancer are often accompanied by gallstones and chronic cholecystitis, which are easily confused with these diseases in the early stage and are often diagnosed at an advanced stage. What about the prognosis of gallbladder cancer? The incidence rate of gallbladder cancer in the United States is about 2.5/100,000, and there is no particularly accurate data in China. The prognosis of gallbladder cancer is very poor, with a median survival of about 10 months. Preoperative routine laparoscopic exploration is not advocated for gallbladder cancer because of the low rate of positive findings, but laparoscopic exploration for stage T3 gallbladder cancer may be helpful for treatment planning changes. If patients with gallbladder cancer who have already developed peri-abdominal trunk and para-abdominal aortic lymph node metastases should be considered to be in IVb, the prognosis is very poor and surgical resection is not recommended anymore. In fact, these metastases should be detected preoperatively by imaging, while avoiding patients to undergo the pain of open surgery. Most patients with gallbladder cancer have a history of gallstones or chronic cholecystitis. Gallbladder polyps are also a high risk factor for gallbladder cancer, but less so compared to stones. For example, for T1b gallbladder cancer, simple cholecystectomy is not enough, but in clinical practice, we see many patients with accidental gallbladder cancer, who often undergo surgical removal of gallbladder because of gallstones or cholecystitis and are found to be gallbladder cancer after surgery, and are T1b or even T2, are not recommended to continue surgery, or patients who are found to have lymph node metastasis after surgery The patients were not recommended to undergo postoperative adjuvant chemoradiotherapy either. Chemotherapy is still the first choice for advanced gallbladder cancer, but individualized treatment plans should be formulated through MDT team discussions. Radical surgery combined with postoperative adjuvant chemotherapy or chemoradiotherapy is recommended for mid-stage gallbladder cancer to prolong the survival of patients. Gallbladder cancer is more likely to occur in middle-aged and elderly women, and patients with previous gallstones, especially those larger than 2 cm or filled stones, a long history of chronic cholecystitis, significant thickening of the gallbladder wall, gallbladder atrophy, or polyp-like changes of more than 1 cm, are recommended to have close review and preventive removal of the gallbladder if necessary.