Some early-stage primary liver cancer patients may reach clinical cure, but not all liver cancer patients can be cured, which is related to disease progression, therapeutic efficacy, patient’s own situation and so on. Primary liver cancer is one of the common malignant tumors in the digestive system, and its treatment options need to be judged according to the stage (tumor size, location, metastasis, etc.), the patient’s own condition and other factors. The prognosis of cancer is generally assessed by survival rate, not cure. 1. For early stage liver cancer patients, surgical resection is mostly used for treatment, and some patients can be regularly rechecked after surgery without other treatments, and the prognosis is generally better, but there are also studies claiming that the 5-year recurrence rate of liver cancer after surgery is about 40%~70%, and the 5-year survival rate is 60%-70%. 2. Intermediate stage is often progressive, only through surgical resection can not completely control the disease progression, and postoperative treatment is usually assisted by targeted therapy, immunotherapy, interventional therapy, radiotherapy and so on. Patients have lost the chance of cure and need active treatment to improve the prognosis. 3. Advanced liver cancer has distant metastasis and the general condition may be poor (e.g. malignant disease), at this time, the opportunity of surgical resection is often lost, and the disease can be controlled by targeted therapy, immunotherapy, interventional therapy and radiotherapy. Research shows that the 1-year survival rate of advanced liver cancer patients is only about 20%, which has lost the chance of cure and needs active treatment to improve the prognosis. In conclusion, most liver cancer patients cannot achieve cure. For patients who are suspected or diagnosed with liver cancer, it is recommended to go to regular hospitals to evaluate their conditions, follow the doctor’s instructions, and choose appropriate treatment plans to avoid delaying their conditions.