Zhuji’s 76-year-old grandmother, Zhou, was already debilitated when her family accompanied her to the clinic. It was not expected that an ordinary oral examination would reveal a serious disease hidden in her body. The company’s main business is to provide a wide range of products and services to the public. On September 18, after the mouth ulcer recurred again, the tongue and lips were swollen and painful, and it was aggravated after spraying watermelon cream, so she went to the Stomatological Hospital of Zhejiang University School of Medicine with the assistance and attention of her family. After the consultation with Dr. He Hong, director of the oral mucosa department and deputy chief of the comprehensive department, combined with Zhou’s previous medical history and the hard, cauliflower-shaped oral ulcers that recurred again, it was felt that Zhou’s oral ulcers were not that simple. ”The first is the possibility of a malignant tumor that could trigger an infection, and the second is a systemic disease such as tuberculosis pending discharge. Re-hospitalization was recommended. Grandma Zhou’s laboratory results showed that she had more than 20,000 white blood cells (4,000-10,000 in healthy people) and her hemoglobin (hemoglobin) was only 6.5 g/L (10-13 g/L in healthy people), and she was diagnosed with acute leukemia by bone marrow aspiration. Dr. Hong He said the patient had reached the cachexia stage (the weakened stage of the body after malignancy). Cachexia” in general, acute leukemia usually manifests as anemia, bleeding gums or broken wounds prone to infection, but there are also clinical manifestations of leukemic cellular clusters with ulcers on the skin and five senses. Zhou’s mother may be one such rare manifestation.” Director He Hong said that Auntie Zhou’s symptoms had reached the point of malignancy. ”Zhou’s aunt may have leukemia early, but because it has not been diagnosed, the virus through various ways to make the body metabolism changes, the body can not absorb nutrients from the outside world, lost a lot of nutrients, the body oxidation process is weakened, nutrients can not be fully utilized, oral ulcers are only one of the symptoms manifestations.” In addition to the symptoms, once diagnosed with acute leukemia, high doses of chemotherapy myelosuppression will be used, and these high doses of applied antimetabolic chemotherapy drugs will cause the beginning of oral mucosal bleeding, edema and even ulcers, pain is intense. ”So the treatment of acute leukemia while to improve the quality of life, it is more important to care for the oral cavity.” Director He Hong said that under the routine, patients are advised to add mycoplasma, vitamin B6, vitamin B2, gentamicin and lidocaine to saline to prepare a mouthwash to clear heat and detoxify the throat and benefit the pharynx. In addition, before and after meals and before bedtime alternate gargle, so that the mouth to maintain an alkaline environment, inhibit the growth of fungi in the oral cavity, to prevent oral fungal infections have a role. “To prevent oral bleeding and infections caused by oral ulcers, patients are also required to brush their teeth with soft-haired toothbrushes or cotton swabs, avoid toothpicks to pick their teeth, and advocate patients to eat light, less crumbly soft food and avoid fried food or hard food to prevent gum and oral mucosa damage.” What to do if you suspect you have a malignant mouth ulcer? Director He Hong introduced, like Zhou Da Ma such patients in the clinical uncommon, so easy to be ignored, so she reminded, “I hope the public to have a proper understanding of oral diseases, that is, oral cavity such as problems are not only so simple as the surface, just the oral cavity should pay attention to and deal with enough aspects, but also to consider sometimes related to systemic diseases , especially repeated cauliflower-shaped, the Malignant oral ulcers with deep red edges and hard texture are likely to be precursors or manifestations of malignant diseases. Once you can’t judge your situation, don’t be overly alarmed and seek immediate examination by an experienced doctor.”