Jealousy is a normal human psychological phenomenon, but if it exceeds the degree, it is a pathological jealousy, which is often seen in people with paranoid personality and psychological characteristics. It has a very negative impact on interpersonal relationships and career success. Jealousy between husband and wife (commonly known as jealousy) is the killer of happy families and often causes serious family tragedies. This pathological jealousy is often considered as “serious feudalism”, “narrow-minded”, “jealous”, etc., which is not easy to attract attention. Shakespeare’s famous tragedy “Othello” describes the brave and warlike Moorish commander Othello, who was deceived and instigated by a treacherous man, became seriously suspicious of his beloved wife Desdemona, killed her and then committed suicide out of regret, causing a tragedy that has been regretted for ages. Some European psychiatrists borrowed this story and named the suspicion of his wife’s affair or infidelity as “Othello syndrome”. The act of killing one’s wife because of suspicion can happen to a mentally ill person with mild delusions, but it can also happen to a normal person who is subjective, suspicious, narrow-minded, irritable, jealous or feudalistic, and the latter is not characterized by psychotic delusions of jealousy, and a strict distinction must be made between them. A delusion is a paranoid belief of a psychiatric patient, which has no basis in fact, is absurd, does not correspond to the facts, and is completely incompatible with the patient’s education and social status, but the patient is convinced, and cannot be corrected or persuaded by general reasoning or education. Delusions are one of the elements that distinguish true psychosis. Patients with delusions can be nearly “normal” in appearance, “articulate” in speech, and able to maintain some ability to work and live, but they should be considered seriously mentally ill and should be actively treated and supervised to avoid accidents. ”Adulterous delusion” is one of the jealous delusions, which is characterized by the patient’s unfounded suspicion that the spouse is having an affair or committing unchaste adultery. As a result of the delusion, the patient becomes suspicious of his or her spouse and follows him or her around. When he or she finds his or her spouse occasionally in contact with the opposite sex, he or she assumes that the relationship is improper and does a series of absurd and ridiculous things. Normal “jealousy” usually does not have much effect on people, and sometimes it can play a good role. However, pathological jealousy can be seen in various mental illnesses, including schizophrenia, depression, bipolar disorder, neurosis, etc. This disease often has a serious impact on the patient’s work, family and life. Therefore, it is important to seek medical attention in a timely manner.